Clinical Characteristics of Diabetic Ketoacidosis in Children with Newly Diagnosed Type 1 Diabetes in Addis Ababa, Ethiopia: A Cross-Sectional Study

نویسندگان

  • Helen Siyoum Atkilt
  • Muluken Gizaw Turago
  • Balewgizie Sileshi Tegegne
چکیده

BACKGROUND Diabetic ketoacidosis (DKA) is one of the most serious acute complications of type 1 diabetes (T1D) and the leading cause of morbidity and mortality in children with T1D. This study was aimed at assessing the prevalence and associated factors of DKA in children with newly diagnosed T1D in Addis Ababa. METHODS A hospital based cross-sectional study was conducted in selected hospitals in Addis Ababa. Children below the age of 12 years with DKA who were admitted to the pediatric ward in the selected hospitals between January 2009 and December 2014 and the residence of Addis Ababa were included. DKA was defined as children below the age of 12 years who have blood glucose level ≥250mg/dl, ketonuria, and ketonemia and diagnosed being T1D patient for the first time. Descriptive statistics was performed using frequency distribution, mean, median, tables, and graphs. Logistic regression analysis was used to identify independent factors associated with the prevalence of DKA in children with newly diagnosed T1D. RESULTS Of 395 DKA patients who were hospitalized during the five-year period, 142(35.8%) presented with DKA at first diagnosis of diabetes. On the other hand 253 (64.2%) children with DKA had longstanding T1D. Independent factors associated with DKA include: Age category 2-4.49years, 7-9.49 years and ≥9.5years (Adjusted odd ratio (AOR) = 3.14[1.21,8.06]), 3.44(1.39,8.49) and 4.02(1.68,9.60), respectively); parents' knowledge on the sign and symptoms of DKA (AOR = 0.51[0.27, 0.95]); sign and symptoms of DKA before the onset of DKA (AOR = 0.35[0.21, 0.59]) and infection prior to DKA onset (AOR = 3.45[1.97, 6.04]). CONCLUSIONS The overall proportion of children diagnosed with DKA and new onset of T1D in Addis Ababa was high. In particular, children between 9-12 years of age and children whose parents did not know the sign and symptoms of DKA had a high risk of DKA at primary diagnosis of T1D.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی فاکتور‌های مستعد کننده، عوارض و پیش آگهی در کودکان مبتلا به کتواسیدوز دیابتی در زنجان

Background and Objective: Diabetic ketoacidosis is one of the most common and life threatening complications in children with diabetes mellitus. The aim of this study was to evaluate predisposing factors, complications and prognosis of the patients with diabetic ketoacidosis admitted to Zanjan hospitals. Materials and Methods: The records of patients with DKA admitted to Mousavi and Vali-e Asr ...

متن کامل

Frequency of Diabetic Ketoacidosis and Severe Hypoglycemia in Children with Type 1 Diabetes

Background and Objective: Diabetic ketoacidosis and severe hypoglycemia are common and recurrent acute complications of type 1 diabetes and are associated with high mortality and morbidity. The aim of this study was to determine the frequency of diabetic ketoacidosis and hypoglycemia in children with type 1 diabetes. Methods: In this retrospective cross-sectional study, 480 patients with type 1...

متن کامل

Prevalence of Retinopathy in Patients with Newly Diagnosed Type 2 Diabetes Mellitus at the Diabetes Center of 5th Azar Hospital in Gorgan

Introduction: Diabetic retinopathy is one of the most important complications of type 1 and 2 diabetes, which is the most important cause of blindness in people aged 20 to 74. This study aimed to determine the prevalence of retinopathy in newly diagnosed type 2 diabetes mellitus at the Diabetes Center of 5th Azar Hospital in Gorgan. Materials and Methods: A total of 260 patients with newly diag...

متن کامل

Diabetes mellitus in Addis Ababa, Ethiopia: admissions, complications and outcomes in a large referral hospital.

SETTING The Black Lion Referral Hospital, Addis Ababa, Ethiopia. OBJECTIVE To document indications for admission, complications and outcomes of patients with diabetes mellitus (DM) admitted between 2010 and 2013. DESIGN A descriptive retrospective study using medical files. RESULTS Of 8048 admissions, 523 (6.5%) had DM; of these, 418 medical records were retrieved: 301 (72%) patients had ...

متن کامل

Sociodemographic, clinical, and psychosocial factors associated with depression among type 2 diabetic outpatients in Black Lion General Specialized Hospital, Addis Ababa, Ethiopia: a cross-sectional study.

BACKGROUND Depression is a common comorbidity among patients with type 2 diabetes. There are several reports supporting a bidirectional association between depression and type 2 diabetes. However, there is limited data from non-western countries. Therefore, the aim of this study was to assess the sociodemographic, clinical, and psychosocial factors associated with co-morbid depression among typ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 12  شماره 

صفحات  -

تاریخ انتشار 2017